DanceTherParkinsonV1, Main, Exploration, bibRecord, 000242

Protein oxidative modifications in the aging brain: consequence for the onset of neurodegenerative disease

Identifieur interne : 000242 ( Main/Exploration ); précédent : 000241; suivant : 000243

Protein oxidative modifications in the aging brain: consequence for the onset of neurodegenerative disease

Auteurs : Stefanie Grimm [Allemagne] ; Annika Hoehn [Allemagne] ; Kelvin J. Davies [États-Unis] ; Tilman Grune [Allemagne]

Source :

Free radical research [ 1071-5762 ] ; 2010.

RBID : PMC:3675897

Abstract

The free radical theory of aging proposes the accumulation of altered, less active and toxic molecules of DNA, RNA, proteins and lipids caused by reactive oxygen species and reactive nitrogen species. Neurodegenerative disorders are characterized by an abnormal accumulation of oxidatively damaged macromolecules inside cells and in the extracellular space. Proteins involved in the formation of aggregates are β-amyloid, tau, α-synuclein, parkin, prion proteins and proteins containing polyglutamine. These abnormal aggregated proteins influence normal cellular metabolism. Additionally, deposition of abnormal proteins induces oxidative stress and proteasomal as well as mitochondrial dysfunction that ultimately lead to neuronal cell death.

In this review we focus on the impact of oxidative and nitrative stress in the aging brain and, consequently, on the generation of modified proteins, as these post-translational modifications are assumed to play an important role in the development of neurodegenerative diseases.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675897

DOI: 10.3109/10715762.2010.512040
PubMed: 20815785
PubMed Central: 3675897

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Protein oxidative modifications in the aging brain: consequence for the onset of neurodegenerative disease</title>
<author><name sortKey="Grimm, Stefanie" sort="Grimm, Stefanie" uniqKey="Grimm S" first="Stefanie" last="Grimm">Stefanie Grimm</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Straße 24, 07743 Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Straße 24, 07743 Jena</wicri:regionArea>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">Institute of Biological Chemistry and Nutrition, University Hohenheim, Garbenstrasse 28, 70593 Stuttgart, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Biological Chemistry and Nutrition, University Hohenheim, Garbenstrasse 28, 70593 Stuttgart</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Stuttgart</region>
<settlement type="city">Stuttgart</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoehn, Annika" sort="Hoehn, Annika" uniqKey="Hoehn A" first="Annika" last="Hoehn">Annika Hoehn</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Straße 24, 07743 Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Straße 24, 07743 Jena</wicri:regionArea>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">Institute of Biological Chemistry and Nutrition, University Hohenheim, Garbenstrasse 28, 70593 Stuttgart, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Biological Chemistry and Nutrition, University Hohenheim, Garbenstrasse 28, 70593 Stuttgart</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Stuttgart</region>
<settlement type="city">Stuttgart</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Davies, Kelvin J" sort="Davies, Kelvin J" uniqKey="Davies K" first="Kelvin J." last="Davies">Kelvin J. Davies</name>
<affiliation wicri:level="4"><nlm:aff id="A3">Ethel Percy Andrus Gerontology Center of the Davis School of Gerontology; and Division of Molecular & Computational Biology, Department of Biological Sciences of the College of Letters, Arts & Sciences, the University of Southern California, Los Angeles, California 90089-0191, U.S.A.</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Ethel Percy Andrus Gerontology Center of the Davis School of Gerontology; and Division of Molecular & Computational Biology, Department of Biological Sciences of the College of Letters, Arts & Sciences, the University of Southern California, Los Angeles, California 90089-0191</wicri:regionArea>
<orgName type="university">Université de Californie du Sud</orgName>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grune, Tilman" sort="Grune, Tilman" uniqKey="Grune T" first="Tilman" last="Grune">Tilman Grune</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Straße 24, 07743 Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Straße 24, 07743 Jena</wicri:regionArea>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20815785</idno>
<idno type="pmc">3675897</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675897</idno>
<idno type="RBID">PMC:3675897</idno>
<idno type="doi">10.3109/10715762.2010.512040</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">000267</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000267</idno>
<idno type="wicri:Area/Pmc/Curation">000155</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000155</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000149</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000149</idno>
<idno type="wicri:Area/Ncbi/Merge">000063</idno>
<idno type="wicri:Area/Ncbi/Curation">000063</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000063</idno>
<idno type="wicri:doubleKey">1071-5762:2010:Grimm S:protein:oxidative:modifications</idno>
<idno type="wicri:Area/Main/Merge">000242</idno>
<idno type="wicri:Area/Main/Curation">000242</idno>
<idno type="wicri:Area/Main/Exploration">000242</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Protein oxidative modifications in the aging brain: consequence for the onset of neurodegenerative disease</title>
<author><name sortKey="Grimm, Stefanie" sort="Grimm, Stefanie" uniqKey="Grimm S" first="Stefanie" last="Grimm">Stefanie Grimm</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Straße 24, 07743 Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Straße 24, 07743 Jena</wicri:regionArea>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">Institute of Biological Chemistry and Nutrition, University Hohenheim, Garbenstrasse 28, 70593 Stuttgart, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Biological Chemistry and Nutrition, University Hohenheim, Garbenstrasse 28, 70593 Stuttgart</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Stuttgart</region>
<settlement type="city">Stuttgart</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoehn, Annika" sort="Hoehn, Annika" uniqKey="Hoehn A" first="Annika" last="Hoehn">Annika Hoehn</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Straße 24, 07743 Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Straße 24, 07743 Jena</wicri:regionArea>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">Institute of Biological Chemistry and Nutrition, University Hohenheim, Garbenstrasse 28, 70593 Stuttgart, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Biological Chemistry and Nutrition, University Hohenheim, Garbenstrasse 28, 70593 Stuttgart</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Stuttgart</region>
<settlement type="city">Stuttgart</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Davies, Kelvin J" sort="Davies, Kelvin J" uniqKey="Davies K" first="Kelvin J." last="Davies">Kelvin J. Davies</name>
<affiliation wicri:level="4"><nlm:aff id="A3">Ethel Percy Andrus Gerontology Center of the Davis School of Gerontology; and Division of Molecular & Computational Biology, Department of Biological Sciences of the College of Letters, Arts & Sciences, the University of Southern California, Los Angeles, California 90089-0191, U.S.A.</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Ethel Percy Andrus Gerontology Center of the Davis School of Gerontology; and Division of Molecular & Computational Biology, Department of Biological Sciences of the College of Letters, Arts & Sciences, the University of Southern California, Los Angeles, California 90089-0191</wicri:regionArea>
<orgName type="university">Université de Californie du Sud</orgName>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grune, Tilman" sort="Grune, Tilman" uniqKey="Grune T" first="Tilman" last="Grune">Tilman Grune</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Straße 24, 07743 Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Straße 24, 07743 Jena</wicri:regionArea>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Free radical research</title>
<idno type="ISSN">1071-5762</idno>
<idno type="eISSN">1029-2470</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">The free radical theory of aging proposes the accumulation of altered, less active and toxic molecules of DNA, RNA, proteins and lipids caused by reactive oxygen species and reactive nitrogen species. Neurodegenerative disorders are characterized by an abnormal accumulation of oxidatively damaged macromolecules inside cells and in the extracellular space. Proteins involved in the formation of aggregates are β-amyloid, tau, α-synuclein, parkin, prion proteins and proteins containing polyglutamine. These abnormal aggregated proteins influence normal cellular metabolism. Additionally, deposition of abnormal proteins induces oxidative stress and proteasomal as well as mitochondrial dysfunction that ultimately lead to neuronal cell death.</p>
<p id="P2">In this review we focus on the impact of oxidative and nitrative stress in the aging brain and, consequently, on the generation of modified proteins, as these post-translational modifications are assumed to play an important role in the development of neurodegenerative diseases.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>États-Unis</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>Californie</li>
<li>District de Stuttgart</li>
</region>
<settlement><li>Los Angeles</li>
<li>Stuttgart</li>
</settlement>
<orgName><li>Université de Californie du Sud</li>
</orgName>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Grimm, Stefanie" sort="Grimm, Stefanie" uniqKey="Grimm S" first="Stefanie" last="Grimm">Stefanie Grimm</name>
</noRegion>
<name sortKey="Grimm, Stefanie" sort="Grimm, Stefanie" uniqKey="Grimm S" first="Stefanie" last="Grimm">Stefanie Grimm</name>
<name sortKey="Grune, Tilman" sort="Grune, Tilman" uniqKey="Grune T" first="Tilman" last="Grune">Tilman Grune</name>
<name sortKey="Hoehn, Annika" sort="Hoehn, Annika" uniqKey="Hoehn A" first="Annika" last="Hoehn">Annika Hoehn</name>
<name sortKey="Hoehn, Annika" sort="Hoehn, Annika" uniqKey="Hoehn A" first="Annika" last="Hoehn">Annika Hoehn</name>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Davies, Kelvin J" sort="Davies, Kelvin J" uniqKey="Davies K" first="Kelvin J." last="Davies">Kelvin J. Davies</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Psychologie/explor/DanceTherParkinsonV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000242 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000242 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Psychologie
   |area=    DanceTherParkinsonV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3675897
   |texte=   Protein oxidative modifications in the aging brain: consequence for the onset of neurodegenerative disease
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:20815785" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a DanceTherParkinsonV1

This area was generated with Dilib version V0.6.35.
Data generation: Sun Aug 9 17:42:30 2020. Site generation: Mon Feb 12 22:53:51 2024

Danse-thérapie et Parkinson

Protein oxidative modifications in the aging brain: consequence for the onset of neurodegenerative disease

Protein oxidative modifications in the aging brain: consequence for the onset of neurodegenerative disease

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Danse-thérapie et Parkinson
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.